Should we sterilize all flexible endoscopes? We seem to have been discussing this question for a very long time. I first gave a presentation around this topic in 2012 and some 6 years later we still debate where the to draw the line between those that need to be sterilized, those that should be sterilized and those that don’t need to be. Perhaps because endoscope technology changes so quickly we will always have this discussion. Or maybe the duodenoscope cleaning issues have ignited the debate again.